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Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial

In this study, villages in northwest China were randomized for all pregnant women to take either daily folic acid (control), iron with folic acid (IFA), or multiple micronutrient supplements (MMS) with a recommended allowance of 15 vitamins and minerals. Birth weight was 42 g higher in the MMS group compared with the folic acid group. IFA was associated with a significantly reduced risk of early preterm delivery. There was a significant increase in haemoglobin concentration in both IFA and MMS groups compared with folic acid alone. There were no significant differences for perinatal mortality, but IFA was associated with a significantly reduced early neonatal mortality by 54%.

British Medical Journal Zeng et al. August 2008
  • Asia
  • Research
  • Scientific publication