Micronutrient deficiencies in Latin America are a public health concern, nonetheless, lack of information still exists in many countries, so that the true magnitude of the problem remains unclear. The objective was to summarises experiences that can inform the development of policies and programs to address micronutrient deficiencies through supplementation in pregnant women and children under five years of age in Latin America. A review of the most evidence on the effects of micronutrients supplementation, focusing on pregnant women and children under five years of age was done. Several resources and experiences exist that can help favor the development of programs that can realize this biological and programmatic potential. There is need for continuous efforts to augment coverage and achieve results that can translate into economic benefits for individuals, families, and nations.