This article shares key learnings and recommendations for the integration of multiple micronutrient supplements (MMS) into health programs of low- and middle-income countries (LMICs). It is a situation analysis that offers a framework on the market, manufacturing and policy enablers and barriers for the local procurement and production of multiple micronutrient supplements (MMS) in three high-burden countries in South Asia and sub-Saharan Africa (Bangladesh, Madagascar and Tanzania), and includes learnings for other countries interested in introducing MMS into health programs.