Evidence outlined in this paper shows that multiple micronutrient supplements (MMS) are a highly cost-effective way to prevent many adverse antenatal and perinatal outcomes. The article also describes the work of the MMS Technical Advisory Group (MMS-TAG) including: the establishment of a communications hub to advise and document global program implementation; the production of generic technical reference materials that could be adapted to the context of adopting countries; and the provision of technical support when needed to address issues that emerge.