Despite several strategies existing for anemia prevention and control, it has been the major public health important problem in the world. Numerous immediate and long-term health issues were reported in children who have history of anemia including decreased work productivity in adult hood period. Although analyzing data on burden and risk factors of anemia are the recommended action areas of World Health Organization framework for accelerating anemia reduction, the aggregated national burden and contributors of anemia in Ethiopia has not been determined so far. Therefore, this systematic and meta-analysis study is aimed to assess the pooled prevalence and associated factors of anemia among children aged 6–23 months in Ethiopia.