This double-blind randomized controlled trial in rural Vietnam assessed individual, household, and programmatic predictors of supplement adherence before conception for iron, iron-folic acid (IFA), and micronutrient supplements and during pregnancy for IFA. Key determinants of adherence included socio-economic status (SES), ethnicity, occupation (farmer), and parity which may be helpful for targeting women for counseling on supplement adherence. Increased contact with village health workers was positively associated with adherence to micronutrient supplementation both before conception and during pregnancy indicating the need for resources to support community outreach to women of reproductive age.