In low and middle‐income countries, addressing maternal and child nutrition needs is crucial. Prenatal multiple micronutrient supplementation (MMS) holds promise in reducing low birthweight and preterm births. Ethiopia is considering a transition from the provision of iron‐folate supplementation to the provision of MMS in antenatal care, guided by WHO guidelines. This paper explores stakeholders’ early perceptions and experiences in piloting that transition in five Ethiopian regions, informing decision making about future policy and scale‐up.