This study aimed to analyze available experiences of prenatal iron-folic acid (IFA) and multiple micronutrient interventions to distill learning for their effective planning and large-scale implementation in Central America, Southeast Asia, South Asia, and Sub-Saharan Africa. The findings suggest that to successfully implement supplementation interventions and achieve sustainable-permanent solutions efforts must focus on factors and processes related to quality, cost-effectiveness, coverage, utilization, demand, outcomes, impacts, and sustainability of programs including strategic analysis, management, collaborations to pilot a project, and careful monitoring, midcourse corrections, supervision, and logistical-support to gradually scaling it up.