This article summarizes the current state of knowledge about multiple micronutrient (MMN) interventions from the perspective of program and policy decisions. That perspective requires attention not only to biological benefits but also to the distribution of benefits in a population and to the examination of intervention cost and harm relative to benefits. Research on MMN is not far enough along to address many program and policy concerns, as the focus has been primarily on the potential biological benefit assessed through regimen or delivery efficacy trials. This article suggests that program efficacy trials, which assess the efficacy of an intervention implemented within a public health program are much more useful for policy and program considerations.