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Multimicronutrient Supplementation for Undernourished Pregnant Women and the Birth Size of Their Offspring

This randomized, double-blind, placebo-controlled trial evaluated the effect of multimicronutrient supplementation (MMS) for undernourished pregnant women in Delhi, India, on the birth size of their offspring, the incidence of low-birth-weight (LBW) infants, and early neonatal morbidity. The intervention group received a multimicronutrient supplement (MMS) containing 29 vitamins and minerals once a day, from enrollment until delivery. The comparison group received a placebo for 52  days, with 85% compliance. All participants also received iron and folic acid (IFA) supplements. Infants in the micronutrient group were heavier by 98 g and measured 0.80 cm longer and 0.20 cm larger in midarm circumference compared with the placebo group. Incidence of low birth weight declined from 43.1% to 16.2% with multimicronutrient supplementation and that of early neonatal morbidity declined from 28.0% to 14.8%. Therefore, compared with IFA supplementation, MMS given to undernourished pregnant women may reduce the incidence of low birth weight and early neonatal morbidity.

Journal of American Medical Association Pediatrics Gutpa et al. January 2007
  • South Asia
  • Research
  • Scientific publication