This study examined whether multiple micronutrient supplementation (MMS) is more efficacious than supplementation with iron and folic acid (IFA) alone for improving the hemoglobin and iron status of anemic adolescent girls in Bangladesh. The results showed that twice-weekly MMS over 12 weeks significantly improved the status of vitamin A, vitamin C, folic acid, and riboflavin but was not more efficacious compared to supplementation with IFA alone in improving the iron status of anemic adolescent girls. This suggests that more frequent doses may be needed to achieve full benefit.