A randomised, controlled, double masked trial to assess the effects of daily prenatal multimicronutrient supplementation on birth weight (BW) and perinatal mortality in Guinea-Bissau. A total of 2100 pregnant women were recruited through antenatal clinics, of which 1670 completed the trial. The results showed that prenatal micronutrient supplementation increased BW but did not reduce perinatal mortality in this study. Multimicronutrient supplementation with two recommended dietary allowance (RDA) should be considered in future programmes to reduce the proportion of low BW.