This systematic review and meta-analysis was conducted very carefully in order to give up the pooled compliance of Iron and Folic-Acid Supplementation in Sub-Saharan Africa (SSA). Twenty-three studies, which encompassed 24272 pregnant women, were chosen for the analysis. From those, an overall prevalence of compliance with Iron and Folic Acid Supplementation (IFAS) in pregnancy in SSA was 39.2%. However, the result from the meta-analysis showed that women who were counseled on IFAS in their courses of pregnancy, who had knowledge of IFAS, knowledge of anemia, and women who had received a fourth visit for antenatal care (ANC) were more likely to have compliance with IFAS as compared to those who did not.